Fate-mapping and functional dissection reveal perilous influence of type I interferon signaling in mouse brain aging
Abstract Background Aging significantly elevates the risk of developing neurodegenerative diseases.Neuroinflammation is a universal hallmark of neurodegeneration as well as normal brain aging.Which branches of age-related neuroinflammation, and how they precondition the brain toward pathological progression, remain ill-understood.The presence of el